Immune suppression in calves with bovine immunodeficiency virus.
نویسندگان
چکیده
The present study was designed to evaluate the effect of bovine immunodeficiency virus (BIV) infection on immune functions and possible interactions between BIV and other bovine viruses in calves. Ten calves were inoculated intravenously with BIV, and five served as controls. An increased lymphocyte proliferation to BIV gag protein was demonstrated 2 to 6 weeks after BIV inoculation (P < 0.05). Lymphocyte subset differentiation revealed a decreased CD4/CD8 ratio (P < 0.05) during weeks 2 to 7, suggesting a possible immune dysfunction in BIV-infected calves. When the calves were inoculated with bovine herpesvirus type 1 (BHV-1), the antibody response to BHV-1 in BIV-infected calves was delayed and the antibody titers were significantly lower (P < 0.05). Injection of bovine viral diarrhea virus vaccine also elicited a lower neutralizing antibody response in BIV-infected calves. The results indicated that immune suppression occurred in BIV-infected calves.
منابع مشابه
Detection and Identification of Enzootic Bovine Leukosis (EBL) in Calves in Iran
Enzootic bovine leukosis (EBL) is known as bovine lymphosarcoma and normally affects the old cattle. EBL is caused by bovine leukemia virus (BLV), which is generally spread all around the world. This virus is transmitted via bovine blood products within and between cattle herds. Glycoprotein GP51 in the blood is responsible for cattle immune responses to BLV. This virus has been previously dete...
متن کاملStudy on duration of maternal antibodies in calves against Bovine Herpes virus (BHV-1)
In order to estimate the mean of maternal antibody in calves against BHV-1 (Bovine Herpes virus type 1), this study was carried out in a population of calves from non-vaccinated dairy cattle at 2 livestock in Qazvin province. One hundred thirteen sera out of 512 were collected from 1-4 months unvaccinated calves. We used Blocking –Percentage of maternal antibodies against BHV-1, which obtained ...
متن کاملBovine virus diarrhoea-mucosal disease and border disease in Egypt.
In Egypt, bovine virus diarrhoea-mucosal disease (BVD-MD) was initially detected as the result of a serological survey of cattle and sheep, using the serum neutralisation test. In 1970, the causal pestivirus was isolated from bovine calves and buffalo calves with pneumonia and enteritis. Mixed viral infections were also prevalent. Cases of immune tolerance were identified. The Egyptian industry...
متن کاملThe first study of bovine immunodeficiency virus (BIV) and brucellosis co-infection in west-central Iran
Background: BIV is a well-known bovine immunosuppressive cause, but its pathogenesis has not been well characterized. In recent years, it has been hypothesized that infection with BIV might predispose cattle to be infected by other agents. OBJECTIVE: This study was performed to investigate of BIV and Brucella co-infection so that in the future more studies will be done on the issue of predispos...
متن کاملCharacterization of early pathogenic effects after experimental infection of calves with bovine immunodeficiency-like virus.
The early pathogenic effects of bovine immunodeficiency-like virus (BIV) were studied in calves experimentally inoculated with BIV. All animals inoculated with BIV R29-infected cells seroconverted by 6 weeks postinoculation, and BIV was recoverable from each animal at 2 weeks postinoculation. However, levels of BIV replication in vivo appeared to be low. In situ hybridization studies indicated ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical and diagnostic laboratory immunology
دوره 4 2 شماره
صفحات -
تاریخ انتشار 1997